Thomas M. Hyde, M.D., Ph.D.
NIMH
Bldg 10 Room 4N306
Bethesda, MD 20892
hydet@intra.nimh.nih.gov
Biosketch
Dr. Hyde graduated magna cum laude from the University of Pennsylvania in 1978, with a
B.A. in Biology. He then entered the M.D.-Ph.D. combined degree program at the
University of Pennsylvania, graduating in 1984 with a Ph.D. in Anatomy.
His medical and graduate school education were funded with an award from
the Medical Scientist Training Program. Dr. Hyde completed a general
medical internship at the Presbyterian-University of Pennsylvania in
1985. He then moved on to Stanford University, completing a residency
in Neurology in 1988. He served as Chief Resident in Neurology at
Stanford in 1988. In 1990, he was board certified in Neurology.
In 1988, Dr. Hyde became director of the Neurology Consultation
Clinics of the NIMH Neuroscience Center at St. Elizabeths Hospital,
serving until 1996. He also worked collaboratively in the Neuropathology
Section of the Clinical Brain Disorders Branch, IRP, NIMH from 1988-1996.
In 1996, Dr. Hyde became a full time investigator in the Neuropathology
Section of the Clinical Brain Disorders Branch. In addition, he has
served as a Neurology Consultant to the clinical programs of the Clinical
Brain Disorders Branch, IRP, NIMH. Dr. Hyde is the author on over 75
peer-reviewed articles and 25 invited chapters. He is a member of the
American Academy of Neurology,
the Society for Neuroscience, and the Society of Biological Psychiatry
Research Interests
Dr. Hyde is focused upon the neuropathological bases of major
mental illnesses, especially schizophrenia. In the past, he
has worked on a variety of laboratory-based projects examining
receptor, neurotransmitter, and growth factor systems in post-mortem
human brain, employing a wide variety of techniques. He is currently
focused on the application of microarrays and laser capture microscopy
to post-mortem human brain tissue in general and schizophrenia in particular.
He also maintains clinical research activities in the Sibling
Study of the Genetics of Schizophrenia, movement disorders, and dementia.
Representative Publications
- Hyde, T.M., J.C. Ziegler, and D.R. Weinberger:
Psychiatric disturbances in metachromatic leukodystrophy: insights into the neurobiology of psychosis.
Archives of Neurology. 49:401-406, 1992.
- Hyde, T.M., S. Nawroz, T.E. Goldberg, D. Strong, J.L. Ostrem, D.R. Weinberger, and J.E. Kleinman:
Is there cognitive decline in schizophrenia? A cross-sectional study.
British Journal of Psychiatry. 164: 494-500, 1994.
- Egan, M.F., T.M. Hyde, J.B. Bonomo, V.S. Mattay, L.B. Bigelow, T.E. Goldberg, and D.R. Weinberger:
Relative risk of neurological signs in siblings of patients with schizophrenia.
American Journal of Psychiatry. 158:1827-1834, 2002.
- Hamid, E.H., T. M. Hyde, S.E. Bachus, M.F. Egan, B. Kinkead, C.B. Nemeroff, and J.E. Kleinman:
Neurotensin receptor abnormalities in the mesial temporal lobe in schizophrenia.
Biological Psychiatry 15:795-800, 2002.
- Vawter, M.P., J.M. Crook, T.M. Hyde, J.E. Kleinman, D.R. Weinberger, K.G. Becker, and W.J. Freed:
Microarray analysis of gene expression in the prefrontal cortex in schizophrenia.
Schizophrenia Research. 7:571-578, 2002.
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